Effects of armadin on hepatic transaminases in rats with acute generalized peritonitis on the background of diabetes mellitus

The article discusses the issues about effect of Armadin on hepatic transaminase in rats with acute generalized peritonitis background diabetes mellitus. experiment was performed 48 white male adult rats, which were divided into two groups. experimental group – animals simulated against streptozotocin-induced drug “Armadin” (ethylmethylhydroxypyridine succinate) application (n=24). control without pharmacocorrection (n = 24). Diabetes mellitus by a single intraperitoneal injection streptozotocin at dose 60 mg/kg. Acute induced 10% faecal suspension 0.5 ml per 100 g animal weight abdominal cavity laboratory puncture method. Every day for 6 days, received doses We found probable decrease aminotransferase activity 3 study after administration Armadin. Thus, ALT decreased 26.7%, and AST 25.9% compared to group. On 7th study, blood 0.50 ± 0.03 mmol/l, 49.5% lower than this period experiment. Similar changes are observed activity, where, accordingly, it % relative control. positive "Armadin" body AGP STZ-induced diabetes, is manifested restoration functional state liver.